ROARABLE // PRO
GLOBAL DESKS // NYC --:--:-- NYSE
US TAPE
ROAR ▸

SEPN // Septerna Inc.

DES <GO> NASDAQ RQD COCKPIT → CIK 0001984086 ↗
Health Care • Biotechnology: Pharmaceutical Preparations
$45.23 ▲ +0.98 (+2.22%)
MKT CAP: $2.11B • VOL: 200.7K
SEPN // ROARABLE RATING & 5-PILLAR RQD CONFIDENCE 02:00 EST DETERMINISTIC ENGINE
PRIOR: RQD 62/100 [C] (+0 PT) • UNCHANGED
ROARABLE C
RQD CONFIDENCE
62 / 100 +0D
5 X 20-PT QUANT PILLARS
E 0 D 35 C 59 B 70 A 86+
Roarable Hold — Fair / Balanced Risk-Reward
01 MASSIVE / SEC XBRL
Forensic Fundamentals
13 / 20
SOLID
FCF +200% vs NI +31.9% • ROIC-WACC -29.3% • Z 5.87
02 INSTITUTIONAL TAPE & TREND
Whale & Options Flow
13 / 20
SOLID
52W RANGE 70% • VS 200D +4.5% • RSI 60.5
03 SEC XBRL CAPITAL ALLOCATION
Insider & Capital Conviction
[LOCKED] FLAGGED
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04 FRED 90D r-MATRIX
Macro Regime Fit
14 / 20
SOLID
TAILWIND • r(10Y)=+0.00 (+23bp) • r(OAS)=+0.00
05 10-K REDLINE AUDIT
Forensic 10-K Risk
[LOCKED] FLAGGED
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ALERT

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SEPN // CANDLESTICK & AUTO-TRENDLINE WORKSTATION6M: +90.36%▲ RESISTANCE BREAKOUT
2026-10-30O $45.00H $45.43L $43.68C $45.23VOL 223.4K
RES: $42.49SUP: $35.10SMA50: $38.95SMA200: $32.08
$53.14$44.67$36.20$27.73$19.26RES $42.49SUP $35.10$45.232026-04-302026-06-152026-07-312026-09-162026-10-30
SEPN // INSTITUTIONAL BULL VS. BEAR FORENSIC DEBATE
HIGH-CONVICTION LONG CONVICTION: 88/100
BEAR 0
100 BULL

Septerna Inc. (SEPN) exhibits 45.0% gross margins and -20.7% return on invested capital within Health Care (Biotechnology: Pharmaceutical Preparations), balanced against a 24.0x enterprise multiple and 4.8% implied options volatility.

▲ INSTITUTIONAL BULL THESIS (LONG)
01. Operating Leverage & Capital Efficiency Moat

Sustained 45.0% gross profitability converts into -60.0% operating margin and -20.7% ROIC, outpacing sector cost of capital.

ROIC: -20.7% // GM: 45.0%
02. Top-Line Expansion & Cash Conversion

YoY revenue trajectory of +180.0% paired with 5.19% free cash flow yield supports self-funded R&D and capital return.

REV YOY: +180.0% // FCF YLD: 5.19%
03. Balance Sheet Solvency & Forensic Quality

Altman Z-Score of 5.87 and Piotroski F-Score of 6/9 indicate low near-term refinancing stress.

ALTMAN Z: 5.87 // F-SCORE: 6/9
▼ INSTITUTIONAL BEAR THESIS (SHORT / RISK)
01. Multiple Compression & Duration Sensitivity

Trading at 24.0x trailing P/E (— Fwd P/E) leaves valuation vulnerable if real 10Y TIPS yields spike.

P/E: 24.0x // EV/EBITDA: —
02. Options Skew & Event Volatility Risk

Options market prices a ±5.2% implied move with a 0.85 put/call ratio around $45.23 max pain.

IMPL MOVE: ±5.2% // P/C: 0.85
03. Competitive Margin & CapEx Cycle Pressure

Elevated industry capital intensity and customer concentration in Biotechnology: Pharmaceutical Preparations require continuous execution to defend -60.0% net margins.

NET MARGIN: -60.0% // D/E: 0.45x
KEY CATALYST // Upcoming 10-Q/10-K XBRL margin progression, guidance revision vs — forward consensus, and institutional 13F positioning.
MACRO REGIME // Monitor US 10Y Real Yields (DFII10) and High-Yield Credit Spreads (OAS) for beta-adjusted multiple impact (Beta 1.10).
FORM 4 & 13F FLOW OPEN OWN <GO>
FILER SIDE $ VALUE
INSPECT FULL OWNERSHIP LEDGER IN OWN <GO>
UNUSUAL OPTIONS TAPE OPEN OPT <GO>
STRIKE / EXP TYPE PREMIUM
INSPECT GEX & CHAIN IN OPT <GO>
KEY VALUATION & PROFITABILITY RATIOS XBRL FA <GO>
TRAILING P/E —
FORWARD P/E —
EV / EBITDA —
FCF YIELD 5.19%
GROSS MARGIN —
OPERATING MARGIN -60.0%
NET MARGIN -60.0%
ROIC % -20.7%
REV GROWTH YOY +180.0%
DILUTED EPS TTM —
DEBT / EQUITY —
DIVIDEND YIELD 0.00%
RSI-14 MOMENTUM 65.2
5Y EQUITY BETA —
FRED MACRO SENSITIVITY (PEARSON r) ECST <GO>
MACRO CORRELATION CALIBRATION ACTIVE BELOW.
FRED MACRO REGIME STRESS-TEST SIMULATOR // SEPNPEARSON R VARIANCE ENGINE
01 // SELECT FEDERAL RESERVE & CREDIT SHOCK SCENARIO
02 // POSITION NOTIONAL EXPOSURE
HEADLINE STRESS SCORE
75/100SEVERE DRAWDOWN PRESSURE
PRIMARY FACTOR EXPOSURE
DFII10 // -0.61 r
Latest: 2.08%
EST. DIRECTIONAL MOVE
-8.50%
Implied Px: $41.39
EST. DOLLAR VARIANCE
-$4,248
On $50,000 Notional
[LOCKED // MULTI-FACTOR DRAWDOWN HEDGE & MACRO TRIGGER ALERT]

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HEAD-TO-HEAD PEER COMPARISONS COMP <GO>