ROARABLE // PRO
GLOBAL DESKS // NYC --:--:-- NYSE
US TAPE
ROAR ▸

AGIO // Agios Pharmaceuticals Inc.

DES <GO> NASDAQ RQD COCKPIT → CIK 0001439222 ↗
Health Care • Biotechnology: Pharmaceutical Preparations
$37.23 ▼ -0.89 (-2.33%)
MKT CAP: $2.22B • VOL: 984.5K
AGIO // ROARABLE RATING & 5-PILLAR RQD CONFIDENCE 02:00 EST DETERMINISTIC ENGINE
▲ UPGRADE // D- (RQD 39) -> D (RQD 49)
ROARABLE D
RQD CONFIDENCE
49 / 100 +10D
5 X 20-PT QUANT PILLARS
E 0 D 35 C 59 B 70 A 86+
Roarable Sell — Underperform / Distribution Warning
01 MASSIVE / SEC XBRL
Forensic Fundamentals
9 / 20
WARNING
FCF +3.6% vs NI -120% • ROIC-WACC -42.4% • Z 11.84
02 INSTITUTIONAL TAPE & TREND
Whale & Options Flow
15 / 20
SOLID
52W RANGE 63% • VS 200D +17.3% • RSI 56.6
03 SEC XBRL CAPITAL ALLOCATION
Insider & Capital Conviction
[LOCKED] FLAGGED
UNLOCK BELOW TO REVEAL
04 FRED 90D r-MATRIX
Macro Regime Fit
8 / 20
WARNING
HEADWIND • r(10Y)=-0.06 (+23bp) • r(OAS)=-0.17
05 10-K REDLINE AUDIT
Forensic 10-K Risk
[LOCKED] FLAGGED
UNLOCK BELOW TO REVEAL
ALERT

Why did AGIO's Insider & Capital Conviction & Forensic 10-K Risk sub-score just flash a warning? Enter your email to unlock the full 5-Pillar Rating Breakdown + get instant alerts whenever AGIO is Upgraded or Downgraded.

AGIO // CANDLESTICK & AUTO-TRENDLINE WORKSTATION6M: +35.09%▲ ASCENDING CHANNEL
2026-11-02O $38.12H $38.12L $37.23C $37.23VOL 984.5K
RES: $38.80SUP: $29.80SMA50: $33.71SMA200: $31.74
$45.33$40.21$35.09$29.97$24.85RES $38.80SUP $29.80$37.232026-05-042026-06-172026-08-042026-09-172026-11-02
AGIO // INSTITUTIONAL BULL VS. BEAR FORENSIC DEBATE
UNDERWEIGHT CONVICTION: 39/100
BEAR 0
100 BULL

Agios Pharmaceuticals Inc. (AGIO) exhibits 88.3% gross margins and -33.8% return on invested capital within Health Care (Biotechnology: Pharmaceutical Preparations), balanced against a 24.0x enterprise multiple and 4.8% implied options volatility.

▲ INSTITUTIONAL BULL THESIS (LONG)
01. Operating Leverage & Capital Efficiency Moat

Sustained 88.3% gross profitability converts into -60.0% operating margin and -33.8% ROIC, outpacing sector cost of capital.

ROIC: -33.8% // GM: 88.3%
02. Top-Line Expansion & Cash Conversion

YoY revenue trajectory of +48.0% paired with -16.97% free cash flow yield supports self-funded R&D and capital return.

REV YOY: +48.0% // FCF YLD: -16.97%
03. Balance Sheet Solvency & Forensic Quality

Altman Z-Score of 11.84 and Piotroski F-Score of 4/9 indicate low near-term refinancing stress.

ALTMAN Z: 11.84 // F-SCORE: 4/9
▼ INSTITUTIONAL BEAR THESIS (SHORT / RISK)
01. Multiple Compression & Duration Sensitivity

Trading at 24.0x trailing P/E (— Fwd P/E) leaves valuation vulnerable if real 10Y TIPS yields spike.

P/E: 24.0x // EV/EBITDA: —
02. Options Skew & Event Volatility Risk

Options market prices a ±5.2% implied move with a 0.85 put/call ratio around $37.23 max pain.

IMPL MOVE: ±5.2% // P/C: 0.85
03. Competitive Margin & CapEx Cycle Pressure

Elevated industry capital intensity and customer concentration in Biotechnology: Pharmaceutical Preparations require continuous execution to defend -60.0% net margins.

NET MARGIN: -60.0% // D/E: 0.45x
KEY CATALYST // Upcoming 10-Q/10-K XBRL margin progression, guidance revision vs — forward consensus, and institutional 13F positioning.
MACRO REGIME // Monitor US 10Y Real Yields (DFII10) and High-Yield Credit Spreads (OAS) for beta-adjusted multiple impact (Beta 1.10).
FORM 4 & 13F FLOW OPEN OWN <GO>
FILER SIDE $ VALUE
INSPECT FULL OWNERSHIP LEDGER IN OWN <GO>
UNUSUAL OPTIONS TAPE OPEN OPT <GO>
STRIKE / EXP TYPE PREMIUM
INSPECT GEX & CHAIN IN OPT <GO>
KEY VALUATION & PROFITABILITY RATIOS XBRL FA <GO>
TRAILING P/E —
FORWARD P/E —
EV / EBITDA —
FCF YIELD -16.97%
GROSS MARGIN 88.3%
OPERATING MARGIN -60.0%
NET MARGIN -60.0%
ROIC % -33.8%
REV GROWTH YOY +48.0%
DILUTED EPS TTM —
DEBT / EQUITY —
DIVIDEND YIELD 0.00%
RSI-14 MOMENTUM 56.6
5Y EQUITY BETA —
FRED MACRO SENSITIVITY (PEARSON r) ECST <GO>
MACRO CORRELATION CALIBRATION ACTIVE BELOW.
FRED MACRO REGIME STRESS-TEST SIMULATOR // AGIOPEARSON R VARIANCE ENGINE
01 // SELECT FEDERAL RESERVE & CREDIT SHOCK SCENARIO
02 // POSITION NOTIONAL EXPOSURE
HEADLINE STRESS SCORE
75/100SEVERE DRAWDOWN PRESSURE
PRIMARY FACTOR EXPOSURE
DFII10 // -0.61 r
Latest: 2.08%
EST. DIRECTIONAL MOVE
-8.50%
Implied Px: $34.07
EST. DOLLAR VARIANCE
-$4,248
On $50,000 Notional
[LOCKED // MULTI-FACTOR DRAWDOWN HEDGE & MACRO TRIGGER ALERT]

Unblur the exact $50,000 delta-adjusted ETF/options hedge ratio for AGIO & activate live FRED threshold breach alerts.

HEAD-TO-HEAD PEER COMPARISONS COMP <GO>