COMP <GO>
UPB vs ADAG // EV/EBITDA & P/E VALUATION
Upstream Bio Inc. (NASDAQ) VS. Adagene Inc. (NASDAQ) • 15-METRIC TALLY: UPB 2
— ADAG 3
■ METRIC PARITY
LAST: $3.41 (+4.28%) • MKT CAP: $179.1M
valuation
—
LAST: $2.51 (-6.34%) • MKT CAP: $177.0M
valuation
—
15-METRIC INSTITUTIONAL SIDE-BY-SIDE SCORECARD (UPB VS. ADAG)
EMERALD CELL = QUANTITATIVE EDGE
| INSTITUTIONAL METRIC | UPB | ADAG | SPREAD (A - B) | ADVANTAGE | DEDICATED URL |
|---|---|---|---|---|---|
| Gross Profit Margin | — | — | — | TIE | /gross-margins <GO> |
| Return on Invested Capital (ROIC) | -35.00% | -35.00% | 0.00 | TIE | /roic <GO> |
| EV/EBITDA & P/E Valuation ACTIVE | — | — | — | TIE | /valuation <GO> |
| Free Cash Flow Yield | — | -8.85% | — | TIE | /fcf-yield <GO> |
| Operating Margin | -60.00% | -60.00% | 0.00 | TIE | /operating-margins <GO> |
| Net Profit Margin | -60.00% | -60.00% | 0.00 | TIE | /net-margins <GO> |
| Revenue Growth (YoY) | 20.40% | 180.00% | -159.60 | ADAG | /revenue-growth <GO> |
| Dividend Yield & FCF Payout Safety | 0.00% | 0.00% | 0.00 | TIE | /dividend-safety <GO> |
| Altman Z-Score & Debt/Equity | 6.01 | 0.20 | +5.81 | UPB | /balance-sheet <GO> |
| Piotroski F-Score Quality | 3/9 | 5/9 | -2.00 | ADAG | /piotroski-score <GO> |
| Options Implied Move & Put/Call Skew | — | — | — | TIE | /options-implied-move <GO> |
| RSI-14 & 200D SMA Momentum | 40.6 | 43.5 | -2.90 | ADAG | /rsi-technicals <GO> |
| 10Y Yield & FRED Macro Beta | — | — | — | TIE | /macro-sensitivity <GO> |
| Forward P/E Multiple | — | — | — | TIE | /forward-pe <GO> |
| Enterprise Scale & Market Cap | $179.1M | $177.0M | $2.1M | UPB | /market-cap <GO> |
5-YEAR HISTORICAL XBRL REVENUE & MARGIN TRAJECTORY SEC FORM 10-K FY
| FISCAL YEAR | UPB REV | ADAG REV | UPB GROSS % | ADAG GROSS % | UPB FCF | ADAG FCF |
|---|---|---|---|---|---|---|
| FY 2025 | $2.9M | $7.7M | — | — | -$133.4M | -$15.7M |
| FY 2024 | $2.4M | $103.2K | — | — | -$59.7M | -$29.7M |
| FY 2023 | $2.4M | $18.1M | — | — | -$37.9M | -$28.5M |
FRED MACRO REGIME CORRELATION COMPARISON PEARSON r
UPB // BETA —
ADAG // BETA —