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LKFT vs SEPN // EV/EBITDA & P/E VALUATION

Lakefront Biotherapeutics (NASDAQ) VS. Septerna Inc. (NASDAQ) • 15-METRIC TALLY: LKFT 2 — SEPN 0
■ METRIC PARITY
15-METRIC INSTITUTIONAL SIDE-BY-SIDE SCORECARD (LKFT VS. SEPN) EMERALD CELL = QUANTITATIVE EDGE
INSTITUTIONAL METRIC LKFT SEPN SPREAD (A - B) ADVANTAGE DEDICATED URL
Gross Profit Margin — — — TIE /gross-margins <GO>
Return on Invested Capital (ROIC) — -20.70% — TIE /roic <GO>
EV/EBITDA & P/E Valuation ACTIVE — — — TIE /valuation <GO>
Free Cash Flow Yield — 5.19% — TIE /fcf-yield <GO>
Operating Margin — -60.00% — TIE /operating-margins <GO>
Net Profit Margin — -60.00% — TIE /net-margins <GO>
Revenue Growth (YoY) — 180.00% — TIE /revenue-growth <GO>
Dividend Yield & FCF Payout Safety 0.00% 0.00% 0.00 TIE /dividend-safety <GO>
Altman Z-Score & Debt/Equity — 5.87 — TIE /balance-sheet <GO>
Piotroski F-Score Quality — 6/9 — TIE /piotroski-score <GO>
Options Implied Move & Put/Call Skew — — — TIE /options-implied-move <GO>
RSI-14 & 200D SMA Momentum 69.8 65.2 +4.62 LKFT /rsi-technicals <GO>
10Y Yield & FRED Macro Beta — — — TIE /macro-sensitivity <GO>
Forward P/E Multiple — — — TIE /forward-pe <GO>
Enterprise Scale & Market Cap $2.13B $2.11B $19.3M LKFT /market-cap <GO>
5-YEAR HISTORICAL XBRL REVENUE & MARGIN TRAJECTORY SEC FORM 10-K FY
FISCAL YEAR LKFT REV SEPN REV LKFT GROSS % SEPN GROSS % LKFT FCF SEPN FCF
FY 2025 — $46.0M — — — $109.7M
FY 2024 — $1.1M — — — -$69.6M
FY 2023 — $151.0K — — — -$38.7M
FRED MACRO REGIME CORRELATION COMPARISON PEARSON r
LKFT // BETA —
SEPN // BETA —