Stock Ratings / Health Care / SEPN / options

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Septerna Inc. (SEPN) Options Positioning, Max Pain & Unusual Sweeps

$45.23 +2.22% NASDAQ • Live Quote vs Prior Daily Close (Synced Snapshot)

Septerna Inc. (SEPN) carries a Roarable Rating of C (Hold) with 62/100 RQD Confidence. The composite score sits in the neutral Hold band (59–69), meaning current holders don’t need to panic-sell while prospective buyers can wait for a move into the 70+ Buy zone.

ROARABLE C • HOLD / WATCH Cap $2.11B

📤 Share Live RQD Speedometer Card: 𝕏 Post Reddit StockTwits ⬇ Live SVG Card

INTERACTIVE SCENARIO DECK:

🛡️ Portfolio Crash X-Ray

RQD QUANT TACHOMETERHOLD / WATCH • C

JEV AI Jury Split (Battleground)

Cash

SEC

Whale

Impersonal quantitative research (0–100 RQD rubric) — not individualized investment advice. Past performance does not guarantee future results. Full Disclaimer

5-PILLAR SNOWFLAKE RADARRw D+ · Rk B-

Each axis scored 0–20

12M PRICE TARGET CONE+1.8% Base Target

WHALE OPTIONS SNAPSHOT: — (No Active Options Snapshot on file for SEPN)Realized 20D OHLCV Swing Band: ±12.5%

CALL VS. PUT WHALE SHARE

— (No Active Options Snapshot)

Put/Call Ratio: — (No Active Options Snapshot)

MAX-PAIN EXPIRATION MAGNET

— (No Active Options Snapshot)

No active options chain max-pain snapshot on file

HISTORICAL 20D VOLATILITY SWING

±12.5%

Derived from 20D OHLCV bars (No Active Options Snapshot)

Active Strike Call vs. Put Concentration Ladder (SEPN)

— (No Active Options Snapshot) — No unusual CBOE strike concentration anomalies recorded in the current database snapshot for SEPN.

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Whale Flow & Momentum Playbook: Evaluating SEPN & AI Leaders Without Chasing Tops

✓Institutional whale strikes & implied earnings move audit on SEPN
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✓Includes nightly RQD rating-change & forensic signal email alerts on tracked leaders

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SEPN // CANDLESTICK & AUTO-TRENDLINE WORKSTATION6M: +90.36%▲ RESISTANCE BREAKOUT

2026-10-30O $45.00H $45.43L $43.68C $45.23VOL 223.4K

RES: $42.49SUP: $35.10SMA50: $38.95SMA200: $32.08

PRIMARY-SOURCE FORENSICS, SECOND-ORDER LINKS & AI ANALYST DESK

SEPN Dilution Monitor, Expectations Hurdle, Butterfly Connections & Policy Exposure

🦋 SEPN Butterfly Map → + Track SEPN →

Share Count & Dilution Monitor (#25)

Multi-year comparable XBRL diluted share count not disclosed (ETF or recent listing).

Reverse-DCF Expectations Hurdle (#30)

8.0%/yr Implied 5Y Growth

vs. +180.0% actual YoY revenue growth (assuming 9.25% cost of equity & 16.5x terminal multiple).

Ellis Vennor Setup Ledger (#33)

No active Ellis Vennor swing setup published on SEPN today. View full Setup Ledger →

🦋 Documented & Second-Order Butterfly Connections Open Graph →

No direct multi-tier Butterfly edges indexed yet for SEPN. Explore sector supply chains on /butterfly.

AI Analyst Theses, Washington Policy & Company Video

🎬 No recent verified company-specific video clip queued for SEPN today (we never pad ticker pages with unrelated generic clips). Browse Macro Video Desk →

DETERMINISTIC MULTI-FACTOR EQUITY AUDIT • SEC EDGAR XBRL × RQD PEER BENCHMARK

📊 Quantitative Sector Peer Comparison, SEC Filing Delta & Investment FAQ (SEPN)

Health Care Rank #167 of 1016 ⚔️ LKFT vs SEPN Full Matrix →

1. Head-to-Head Health Care Peer Comparison (SEPN vs. LKFT, IMNM, XNCR, SLS)

Industry: Biotechnology: Pharmaceutical Preparations (489 Tracked Issuers)

Across 1016 tracked Health Care securities in the Roarable RQD universe, Septerna Inc. (SEPN) ranks #167 by composite RQD confidence (62/100, grade C) and #254 by equity capitalization ($2.11B). Within this direct 5-issuer industry benchmark cohort, SEPN leads on earnings valuation at N/A trailing P/E, while SEPN leads on capital efficiency and profitability with -20.7% ROIC and — gross margin. SEPN currently leads its immediate peer cohort in composite quantitative strength at 62/100 (C).

Ticker / Company	Roarable Grade	RQD Score	Trailing P/E	Gross Margin	ROIC	1D Change	Market Cap	Head-to-Head
SEPN ACTIVE Septerna Inc.	C	62/100	—	—	-20.7%	+2.22%	$2.11B	Benchmark Subject
LKFT Lakefront Biotherapeutics	C-	61/100	—	—	—	+0.78%	$2.13B	/lkft-vs-sepn →
IMNM Immunome Inc.	D-	38/100	—	—	-35.0%	-2.50%	$2.16B	/imnm-vs-sepn →
XNCR Xencor Inc.	D-	43/100	—	—	-21.3%	-2.60%	$2.17B	/xncr-vs-sepn →
SLS SELLAS Life Sciences Group Inc.	D-	35/100	—	—	-21.8%	-2.17%	$2.05B	/sls-vs-sepn →

2. Multi-Year SEC XBRL Revenue, Cash Flow & Balance-Sheet Trajectory (FY2023–FY2025)

SEC EDGAR 10-K • FILED 2025-12-31 • CIK 0001984086

In its most recent audited fiscal period (FY2025, filed 2025-12-31), Septerna Inc. (SEPN) reported GAAP revenue of $46.0M (+4174.5% vs. FY2024 revenue of $1.1M , and +30331.1% cumulative change since FY2023) , GAAP net income of -$48.9M, operating cash flow of $110.2M, and free cash flow of $109.7M (+257.6% YoY). On the balance sheet, SEPN closed FY2025 with $596.2M in total assets against $0 in total debt (Altman Z-Score: 5.87, Piotroski F-Score: 6/9).

Fiscal Period	Filing Date	Revenue	Net Income	Operating Cash Flow	Free Cash Flow	Total Assets	Total Debt
FY2025 (FY)	2025-12-31	$46.0M	-$48.9M	$110.2M	$109.7M	$596.2M	—
FY2024 (FY)	2024-12-31	$1.1M	-$71.8M	-$67.5M	-$69.6M	$456.6M	—
FY2023 (FY)	2023-12-31	$151.0K	$4.2M	-$38.7M	-$38.7M	—	—

3. SEPN Data-Verified Investor FAQ (RQD Rating, Sector Peers, SEC Forensics & Technicals)

✓ SCHEMA.ORG FAQPAGE JSON-LD ENABLED

Is SEPN stock a Buy, Hold, or Sell right now according to Roarable's RQD model?

As of 2026-11-01, Septerna Inc. (NASDAQ: SEPN) is rated C (Hold / HOLD) by Roarable's 5-pillar RQD engine with a composite confidence score of 62/100 at a spot price of $45.23 (+2.22% 1D, market cap $2.11B). Pillar breakdown: Fundamental Cash Engine 13/20, Institutional 13F & Options Flow 13/20, Executive Insider Alignment 14/20, FRED Macro Regime Fit 14/20, and SEC Balance-Sheet Forensics 8/20. Across 1016 tracked Health Care issuers, SEPN ranks #167 in composite RQD confidence.

How does SEPN compare to LKFT and IMNM in the Health Care sector?

Within the Health Care sector (Biotechnology: Pharmaceutical Preparations), SEPN carries a Roarable C (62/100 RQD), trailing P/E of N/A, gross margin of —, and ROIC of -20.7%. By comparison, LKFT (Lakefront Biotherapeutics) holds a C- grade (61/100 RQD, P/E N/A, ROIC —, cap $2.13B) and IMNM (Immunome Inc.) posts a D- grade (38/100 RQD, P/E N/A, ROIC -35.0%, cap $2.16B). Among the 5-stock peer group, SEPN leads on earnings multiple (N/A) while SEPN leads on capital efficiency (-20.7% ROIC).

What are the biggest fundamental strengths and SEC risk factors for SEPN?

Per SEPN's SEC EDGAR XBRL 10-K filing (FY2025, filed 2025-12-31, CIK 0001984086), Septerna Inc. generated $46.0M in revenue (+4174.5% YoY), -$48.9M in net income, and $109.7M in free cash flow against $596.2M in total assets and $0 in total debt. Key quantitative strengths: Established market leader in Health Care with deep daily trading liquidity.. Primary risk factors monitored: Company executives have done more routine share selling than personal cash buying lately.. Institutional options positioning shows a 50% call / 50% put premium split.

Where is SEPN trading relative to its 50-day, 200-day, and 52-week technical levels?

SEPN last traded at $45.23 (+2.22% on volume of 200,711 shares), positioning the stock +16.12% above its 50-day simple moving average ($38.95) and +40.99% above its 200-day simple moving average ($32.08). Across its 52-week range of $17.55 to $51.10, SEPN sits at the 82.5% percentile with a 14-day RSI of 65.2 (BULLISH MOMENTUM) and an implied next-earnings move of ±12.5% ($39.58 to $50.88).

SEPN Investor FAQ & Complete 8-Part Research Index

100% OPEN ACCESS • SEC EDGAR × CBOE × FRED

What is SEPN's options positioning and volatility profile?

Roarable tracks verified CBOE unusual options sweeps, put/call ratios, and OHLCV realized volatility bands for SEPN.

Direct Sub-Reports: SEPN RQD Cockpit SEPN 12M Forecast SEPN Earnings & Move SEPN Dividends & DRIP SEPN Insiders & 13F SEPN Whale Options SEPN Profit Sankey SEPN News & Why