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Septerna Inc. (SEPN) 12-Month Stock Forecast & Price Target Cone

$45.23 +2.22% NASDAQ • Live Quote vs Prior Daily Close (Synced Snapshot) EXT / AFTER-HRS: $45.32

Septerna Inc. (SEPN) carries a Roarable Rating of C (Hold) with 62/100 RQD Confidence. The composite score sits in the neutral Hold band (59–69), meaning current holders don’t need to panic-sell while prospective buyers can wait for a move into the 70+ Buy zone.

📊 Historical Track Record: Scores of 62/100 (C) historically posted market-perform odds over rolling 90-day windows (+0.7% avg 90D alpha vs SPY) →

ROARABLE C • HOLD / WATCH Cap $2.11B

📤 Share Live RQD Speedometer Card: 𝕏 Post Reddit StockTwits ⬇ Live SVG Card

INTERACTIVE SCENARIO DECK:

🛡️ Portfolio Crash X-Ray

EXT / AFTER-HRS: $45.32 (+0.21%)🧬 Disciplined Float (-0.12% YoY Shares)⚙️ Cash Engine: 13/20 (C) • 238.7% FCF Margin

Verify 90D Bucket Audit →

📊 Historical Track Record: Scores of 62/100 (C) historically posted market-perform odds over rolling 90-day windows (+0.7% avg 90D alpha vs SPY • 54.3% hit rate — wait for RQD ≥ 70 breakout).

Audit Bucket Track Record →

RQD QUANT TACHOMETERHOLD / WATCH • C

JEV AI Jury Split (Battleground)

Cash

SEC

Whale

Impersonal quantitative research (0–100 RQD rubric) — not individualized investment advice. Past performance does not guarantee future results. Full Disclaimer

5-PILLAR SNOWFLAKE RADARRw D+ · Rk B-

Each axis scored 0–20

12M PRICE TARGET CONE+1.8% Base Target

WHALE OPTIONS SNAPSHOT: — (No Active Options Snapshot on file for SEPN)Realized 20D OHLCV Swing Band: ±12.5%

Deterministic 5-Pillar Attribution (62/100 Composite)

🔍 WHY SEPN SCORES 62/100 (C) — TOP 3 DRIVERS2 Bullish Pillars + #1 Risk Drag

▲ #1 Bullish Driver: SEC 10-K Forensic Risk+14/20 pts (23% of score)

Altman Z-Score 5.87 (FORTRESS SAFE (>3.0)) • Piotroski F-Score 6/9

▲ #2 Bullish Driver: Macro Regime Fit+14/20 pts (23% of score)

FRED Regime × Technicals: 83% of 52W Range • RSI-14 at 65.2 (BULLISH MOMENTUM)

▼ #1 Drag / Risk Factor: Insider Conviction & Share Dilution8/20 pts (-12 pt drag)

Disciplined Float (-0.12% YoY Shares) & executive Form 4 sales trim 12 pts from alignment

📈 PAST 4 QUARTERS RQD vs SUBSEQUENT RETURNQ1 → Q2 → Q3 → Current

Q1 (-3Q)

Grade C-$38.37-5.3% Next Q

Q2 (-2Q)

Grade C$36.35+11.2% Next Q

Q3 (-1Q)

Grade C$40.41+11.9% Next Q

Current

Grade C$45.23+0.7% Hist 90D α

Trajectory: C- (54) → C (62)Full Audit →

⚔️ ADVERSARIAL OPPOSING CASE & FORENSIC KILL-SWITCH (WHY THE BULL/BEAR THESIS COULD FAIL)GIDEON ASHMERE // FORENSIC SHORT & KILL-SWITCH DOSSIER

⚔️ Adversarial Opposing Case: Why the SEPN Bull Thesis Could Fail

Gideon Ashmere Forensic Desk →

Even with a 62/100 (C) score, SEPN faces multiple-compression risk if current valuation multiples re-rate toward historical sector medians or if hyperscaler/enterprise customer concentration slows in upcoming 10-Q filings.

⚠️ Forensic Kill-Switch #1

Company executives have done more routine share selling than personal cash buying lately.

⚠️ Forensic Kill-Switch #2

Dilution & Margin Drag: Disciplined Float (-0.12% YoY Shares) — any gross margin slip below 49.5% triggers an automatic RQD downgrade.

⚠️ Forensic Kill-Switch #3

Technical & Forensic Kill-Switch: A daily close below the 50D SMA ($38.95) or 200D SMA ($32.08) invalidates the momentum regime and cuts Target Base ($46.04) toward Bear Floor ($35.91).

🎲 LIVE PREDICTION MARKET ODDS TIED TO $SEPN• $2.4M Crowd Pool • Kalshi / Polymarket Composite

Contract: “SEPN Beats Next Quarter EPS Consensus (Dec 30, 2026) & Holds Above 200D SMA”

YES 62%NO 38%Trade / Inspect Odds →

INTERACTIVE 12-MONTH POSITION SIMULATOR

Drag to Test Your SEPN Position Size: $10,000

Shares at $45.23: 221.1 sh

$1,000$10,000$25,000$50,000$100,000

12M Bear Case FloorTarget $35.91

$7,939

$-2,061 (-20.6%)

12M Consensus BaseTarget $46.04

$10,179

+$179 (+1.8%)

12M Bull Case BreakoutTarget $54.33

$12,012

+$2,012 (+20.1%)

Wall Street Analyst Breakdown & Historical Accuracy Audit (28 Desks)

Street Historical Accuracy: 64/100

● Strong Buy / Buy: 17● Hold: 9● Sell: 2

Wall Street Firm	Stance	12M Target	1Y Accuracy	Track Grade
Morgan StanleyInstitutional Equity Desk	HOLD	$48	74%	A
Goldman SachsSector Coverage Lead	BUY	$51	69%	B
JP MorganUS Large-Cap Research	HOLD	$41	58%	C

ON-DEMAND RQD QUANT WORKSHOP • SPONSORED / PARTNER SPOTLIGHTHosted by Perry Belcher & Roarable Quantitative Research Desk

Scheduled RQD Strong Buys & Whale Accumulation Briefing (SEPN Tape Review)

✓Breakdown of the highest-scoring RQD Green-Light breakouts across our 5,200+ rated universe
✓Forensic Red-Light accounting & dilution traps to review on your watchlist
✓Includes downloadable .ics calendar invite & nightly RQD rating-change email alerts

RQD INSIDER CLUB WAITLIST$49/YR PLANNED

Want Custom AI PineScript / Python Indicators & Priority Rating-Change Alerts?

Join Founding VIP Waitlist (No Card Required) →$100K Arena

SEPN // CANDLESTICK & AUTO-TRENDLINE WORKSTATION6M: +90.36%▲ RESISTANCE BREAKOUT

2026-10-30O $45.00H $45.43L $43.68C $45.23VOL 223.4K

RES: $42.49SUP: $35.10SMA50: $38.95SMA200: $32.08

PRIMARY-SOURCE FORENSICS, SECOND-ORDER LINKS & AI ANALYST DESK

SEPN Dilution Monitor, Expectations Hurdle, Butterfly Connections & Policy Exposure

🦋 SEPN Butterfly Map → + Track SEPN →

Share Count & Dilution Monitor (#25)

Multi-year comparable XBRL diluted share count not disclosed (ETF or recent listing).

Reverse-DCF Expectations Hurdle (#30)

8.0%/yr Implied 5Y Growth

vs. +180.0% actual YoY revenue growth (assuming 9.25% cost of equity & 16.5x terminal multiple).

Ellis Vennor Setup Ledger (#33)

No active Ellis Vennor swing setup published on SEPN today. View full Setup Ledger →

🦋 Documented & Second-Order Butterfly Connections Open Graph →

No direct multi-tier Butterfly edges indexed yet for SEPN. Explore sector supply chains on /butterfly.

AI Analyst Theses, Washington Policy & Company Video

🎬 No recent verified company-specific video clip queued for SEPN today (we never pad ticker pages with unrelated generic clips). Browse Macro Video Desk →

DETERMINISTIC MULTI-FACTOR EQUITY AUDIT • SEC EDGAR XBRL × RQD PEER BENCHMARK

📊 Quantitative Sector Peer Comparison, SEC Filing Delta & Investment FAQ (SEPN)

Health Care Rank #167 of 1016 ⚔️ LKFT vs SEPN Full Matrix →

1. Head-to-Head Health Care Peer Comparison (SEPN vs. LKFT, IMNM, XNCR, SLS)

Industry: Biotechnology: Pharmaceutical Preparations (489 Tracked Issuers)

Across 1016 tracked Health Care securities in the Roarable RQD universe, Septerna Inc. (SEPN) ranks #167 by composite RQD confidence (62/100, grade C) and #254 by equity capitalization ($2.11B). Within this direct 5-issuer industry benchmark cohort, SEPN leads on earnings valuation at N/A trailing P/E, while SEPN leads on capital efficiency and profitability with -20.7% ROIC and — gross margin. SEPN currently leads its immediate peer cohort in composite quantitative strength at 62/100 (C).

Ticker / Company	Roarable Grade	RQD Score	Trailing P/E	Gross Margin	ROIC	1D Change	Market Cap	Head-to-Head
SEPN ACTIVE Septerna Inc.	C	62/100	—	—	-20.7%	+2.22%	$2.11B	Benchmark Subject
LKFT Lakefront Biotherapeutics	C-	61/100	—	—	—	+0.78%	$2.13B	/lkft-vs-sepn →
IMNM Immunome Inc.	D-	38/100	—	—	-35.0%	-2.50%	$2.16B	/imnm-vs-sepn →
XNCR Xencor Inc.	D-	43/100	—	—	-21.3%	-2.60%	$2.17B	/xncr-vs-sepn →
SLS SELLAS Life Sciences Group Inc.	D-	35/100	—	—	-21.8%	-2.17%	$2.05B	/sls-vs-sepn →

2. Multi-Year SEC XBRL Revenue, Cash Flow & Balance-Sheet Trajectory (FY2023–FY2025)

SEC EDGAR 10-K • FILED 2025-12-31 • CIK 0001984086

In its most recent audited fiscal period (FY2025, filed 2025-12-31), Septerna Inc. (SEPN) reported GAAP revenue of $46.0M (+4174.5% vs. FY2024 revenue of $1.1M , and +30331.1% cumulative change since FY2023) , GAAP net income of -$48.9M, operating cash flow of $110.2M, and free cash flow of $109.7M (+257.6% YoY). On the balance sheet, SEPN closed FY2025 with $596.2M in total assets against $0 in total debt (Altman Z-Score: 5.87, Piotroski F-Score: 6/9).

Fiscal Period	Filing Date	Revenue	Net Income	Operating Cash Flow	Free Cash Flow	Total Assets	Total Debt
FY2025 (FY)	2025-12-31	$46.0M	-$48.9M	$110.2M	$109.7M	$596.2M	—
FY2024 (FY)	2024-12-31	$1.1M	-$71.8M	-$67.5M	-$69.6M	$456.6M	—
FY2023 (FY)	2023-12-31	$151.0K	$4.2M	-$38.7M	-$38.7M	—	—

3. SEPN Data-Verified Investor FAQ (RQD Rating, Sector Peers, SEC Forensics & Technicals)

✓ SCHEMA.ORG FAQPAGE JSON-LD ENABLED

Is SEPN stock a Buy, Hold, or Sell right now according to Roarable's RQD model?

As of 2026-11-01, Septerna Inc. (NASDAQ: SEPN) is rated C (Hold / HOLD) by Roarable's 5-pillar RQD engine with a composite confidence score of 62/100 at a spot price of $45.23 (+2.22% 1D, market cap $2.11B). Pillar breakdown: Fundamental Cash Engine 13/20, Institutional 13F & Options Flow 13/20, Executive Insider Alignment 14/20, FRED Macro Regime Fit 14/20, and SEC Balance-Sheet Forensics 8/20. Across 1016 tracked Health Care issuers, SEPN ranks #167 in composite RQD confidence.

How does SEPN compare to LKFT and IMNM in the Health Care sector?

Within the Health Care sector (Biotechnology: Pharmaceutical Preparations), SEPN carries a Roarable C (62/100 RQD), trailing P/E of N/A, gross margin of —, and ROIC of -20.7%. By comparison, LKFT (Lakefront Biotherapeutics) holds a C- grade (61/100 RQD, P/E N/A, ROIC —, cap $2.13B) and IMNM (Immunome Inc.) posts a D- grade (38/100 RQD, P/E N/A, ROIC -35.0%, cap $2.16B). Among the 5-stock peer group, SEPN leads on earnings multiple (N/A) while SEPN leads on capital efficiency (-20.7% ROIC).

What are the biggest fundamental strengths and SEC risk factors for SEPN?

Per SEPN's SEC EDGAR XBRL 10-K filing (FY2025, filed 2025-12-31, CIK 0001984086), Septerna Inc. generated $46.0M in revenue (+4174.5% YoY), -$48.9M in net income, and $109.7M in free cash flow against $596.2M in total assets and $0 in total debt. Key quantitative strengths: Established market leader in Health Care with deep daily trading liquidity.. Primary risk factors monitored: Company executives have done more routine share selling than personal cash buying lately.. Institutional options positioning shows a 50% call / 50% put premium split.

Where is SEPN trading relative to its 50-day, 200-day, and 52-week technical levels?

SEPN last traded at $45.23 (+2.22% on volume of 200,711 shares), positioning the stock +16.12% above its 50-day simple moving average ($38.95) and +40.99% above its 200-day simple moving average ($32.08). Across its 52-week range of $17.55 to $51.10, SEPN sits at the 82.5% percentile with a 14-day RSI of 65.2 (BULLISH MOMENTUM) and an implied next-earnings move of ±12.5% ($39.58 to $50.88).

SEPN Investor FAQ & Complete 8-Part Research Index

100% OPEN ACCESS • SEC EDGAR × CBOE × FRED

What is SEPN's 12-month stock price target?

Septerna Inc. (SEPN) carries a 12-month consensus base price target of $46.04 (+1.8% from $45.23), with a bull-case target of $54.33 and a bear-case floor of $35.91.

Is SEPN stock a Buy, Hold, or Sell right now?

Roarable's 5-Pillar RQD Quant Engine rates SEPN C (Hold — HOLD) with an RQD Confidence score of 62/100.

Direct Sub-Reports: SEPN RQD Cockpit SEPN 12M Forecast SEPN Earnings & Move SEPN Dividends & DRIP SEPN Insiders & 13F SEPN Whale Options SEPN Profit Sankey SEPN News & Why