Spyre Therapeutics Inc. (SYRE) 12-Month Stock Forecast & Price Target Cone

$98.96 -0.79% NASDAQ • Public Delayed / 60s Snapshot

Spyre Therapeutics Inc. (SYRE) carries a Roarable Rating of D+ (Sell) with 57/100 RQD Confidence due to weak cash-flow efficiency and sensitivity to current interest rates. Wait for business cash flow and institutional buying to improve before committing fresh money.

ROARABLE D+ • SELL / AVOID Cap $10.33B
INTERACTIVE SCENARIO DECK:
🛡️ Portfolio Crash X-Ray
RQD QUANT TACHOMETERSELL / AVOID • D+
025507510057
2-of-3 JEV AI Jury Bearish Warning
Cash
SEC
Whale
5-PILLAR SNOWFLAKE RADARRw D · Rk B
Cash (5)Whales (10)SEC (8)Macro (14)CEO (12)
Each axis scored 0–20
12M PRICE TARGET CONE-0.5% Base Target
$116 Bull$99 Base$77 Bear
🔴 SUNDAY NIGHT PREP • 7:00 PM ET
WHALE OPTIONS TUG-OF-WAR:52% Call Buyers ($2.3M)
48% PutsMax Pain: $97.00
INTERACTIVE 12-MONTH POSITION SIMULATOR

Drag to Test Your SYRE Position Size: $10,000

Shares at $98.96: 101.1 sh
$1,000$10,000$25,000$50,000$100,000
12M Bear Case FloorTarget $76.84
$7,765
$-2,235 (-22.4%)
12M Consensus BaseTarget $98.51
$9,955
$-45 (-0.5%)
12M Bull Case BreakoutTarget $116.24
$11,746
+$1,746 (+17.5%)

Wall Street Analyst Breakdown & Historical Accuracy Audit (32 Desks)

Street Historical Accuracy: 64/100
● Strong Buy / Buy: 17● Hold: 9● Sell: 6
Wall Street FirmStance12M Target1Y AccuracyTrack Grade
Morgan StanleyInstitutional Equity DeskHOLD$10274%A
Goldman SachsSector Coverage LeadUNDERPERFORM$10969%B
JP MorganUS Large-Cap ResearchSELL$8858%C
🔴 SUNDAY NIGHT PREP • 7:00 PM ETHosted Live by Perry Belcher & Guest Forensic Quant Desk

Red-Light Warning Desk: How Pros Profit When Overhyped Stocks Crack (Featuring SYRE)

  • ✓Live walkthrough of SYRE's RQD Radar, SEC cash-conversion gap & downside levels
  • ✓3 asymmetric Bear/Hedge setups institutions use when 10-year yields stay elevated
  • ✓Includes instant 24/7 email alert whenever any of your stocks flip to Red
RQD INSIDER CLUB UPGRADE$49/YEAR
Want Plain-English AI Custom Indicators, Daily Pro Trader Video Clips & SMS Crash Alerts?
SYRE // CANDLESTICK & AUTO-TRENDLINE WORKSTATION6M: +29.70%📐 HORIZONTAL RANGE
2026-10-30O $96.78H $98.96L $94.68C $96.56VOL 661.1K
RES: $120.5SUP: $70.80SMA50: $90.06SMA200: $73.22
$115.7$92.75$69.78$46.80$23.83RES $120.5SUP $70.80$96.562026-04-302026-06-152026-07-312026-09-162026-10-30
PRIMARY-SOURCE FORENSICS, SECOND-ORDER LINKS & AI ANALYST DESK

SYRE Dilution Monitor, Expectations Hurdle, Butterfly Connections & Policy Exposure

Share Count & Dilution Monitor (#25)

Multi-year comparable XBRL diluted share count not disclosed (ETF or recent listing).

Reverse-DCF Expectations Hurdle (#30)
15.7%/yr Implied 5Y Growth

vs. +17.6% actual YoY revenue growth (assuming 9.25% cost of equity & 16.5x terminal multiple).

Ellis Vennor Setup Ledger (#33)

No active Ellis Vennor swing setup published on SYRE today. View full Setup Ledger →

🦋 Documented & Second-Order Butterfly Connections Open Graph →

No direct multi-tier Butterfly edges indexed yet for SYRE. Explore sector supply chains on /butterfly.

AI Analyst Theses, Washington Policy & Company Video
🎬 No recent verified company-specific video clip queued for SYRE today (we never pad ticker pages with unrelated generic clips). Browse Macro Video Desk →

SYRE Investor FAQ & Complete 8-Part Research Index

100% OPEN ACCESS • SEC EDGAR × CBOE × FRED

What is SYRE's 12-month stock price target?

Spyre Therapeutics Inc. (SYRE) carries a 12-month consensus base price target of $98.51 (-0.5% from $98.96), with a bull-case target of $116.24 and a bear-case floor of $76.84.

Is SYRE stock a Buy, Hold, or Sell right now?

Roarable's 5-Pillar RQD Quant Engine rates SYRE D+ (Sell — SELL) with an RQD Confidence score of 57/100.