Spyre Therapeutics Inc. (SYRE) Revenue-to-Profit Sankey Flow & SEC XBRL Financials

$98.96 -0.79% NASDAQ β€’ Public Delayed / 60s Snapshot

Spyre Therapeutics Inc. (SYRE) carries a Roarable Rating of D+ (Sell) with 57/100 RQD Confidence due to weak cash-flow efficiency and sensitivity to current interest rates. Wait for business cash flow and institutional buying to improve before committing fresh money.

ROARABLE D+ β€’ SELL / AVOID Cap $10.33B
INTERACTIVE SCENARIO DECK:
RQD QUANT TACHOMETERSELL / AVOID β€’ D+
025507510057
2-of-3 JEV AI Jury Bearish Warning
Cash
SEC
Whale
5-PILLAR SNOWFLAKE RADARRw D Β· Rk B
Cash (5)Whales (10)SEC (8)Macro (14)CEO (12)
Each axis scored 0–20
12M PRICE TARGET CONE-0.5% Base Target
$116 Bull$99 Base$77 Bear
πŸ”΄ SUNDAY NIGHT PREP β€’ 7:00 PM ET
WHALE OPTIONS TUG-OF-WAR:52% Call Buyers ($2.3M)
48% PutsMax Pain: $97.00
VISUAL REVENUE-TO-PROFIT SANKEY WATERFALL β€’ FY 2025 (10-K)

How SYRE Turns Every Dollar of Sales Into Real Bottom-Line Profit

Free Cash Flow:$0 (0% FCF Margin)
Revenue$4.00BGross Profit $0 (0%)Cost of Sales $4.00BOp Profit $0 (0%)OpEx (R&D/SG&A) $0Net Profit$0 (0%)Tax/Other $0

Multi-Year SEC EDGAR XBRL Revenue, Net Profit & Free Cash Flow Trajectory

β–  Revenueβ–  Net Profitβ–  Free Cash Flow
FY23
Rev $886.0K
FY24
Rev $4.00B
FY25
Rev $4.00B
Fiscal YearRevenueGross MarginOp MarginNet ProfitFree Cash FlowROIC %
FY 2025$4.00B0%-5.2%-$155.2M-$169.3M-25.2%
FY 2024$4.00B0%-5.2%-$208.0M-$157.4M-35.1%
FY 2023$886.0K44%-27348%-$338.8M-$99.9M-5.6%
πŸ”΄ SUNDAY NIGHT PREP β€’ 7:00 PM ETHosted Live by Perry Belcher & Guest Forensic Quant Desk

Red-Light Warning Desk: How Pros Profit When Overhyped Stocks Crack (Featuring SYRE)

  • βœ“Live walkthrough of SYRE's RQD Radar, SEC cash-conversion gap & downside levels
  • βœ“3 asymmetric Bear/Hedge setups institutions use when 10-year yields stay elevated
  • βœ“Includes instant 24/7 email alert whenever any of your stocks flip to Red
RQD INSIDER CLUB UPGRADE$49/YEAR
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SYRE // CANDLESTICK & AUTO-TRENDLINE WORKSTATION6M: +29.70%πŸ“ HORIZONTAL RANGE
2026-10-30O $96.78H $98.96L $94.68C $96.56VOL 661.1K
RES: $120.5SUP: $70.80SMA50: $90.06SMA200: $73.22
$115.7$92.75$69.78$46.80$23.83RES $120.5SUP $70.80$96.562026-04-302026-06-152026-07-312026-09-162026-10-30
PRIMARY-SOURCE FORENSICS, SECOND-ORDER LINKS & AI ANALYST DESK

SYRE Dilution Monitor, Expectations Hurdle, Butterfly Connections & Policy Exposure

Share Count & Dilution Monitor (#25)

Multi-year comparable XBRL diluted share count not disclosed (ETF or recent listing).

Reverse-DCF Expectations Hurdle (#30)
15.7%/yr Implied 5Y Growth

vs. +17.6% actual YoY revenue growth (assuming 9.25% cost of equity & 16.5x terminal multiple).

Ellis Vennor Setup Ledger (#33)

No active Ellis Vennor swing setup published on SYRE today. View full Setup Ledger β†’

πŸ¦‹ Documented & Second-Order Butterfly Connections Open Graph β†’

No direct multi-tier Butterfly edges indexed yet for SYRE. Explore sector supply chains on /butterfly.

AI Analyst Theses, Washington Policy & Company Video
🎬 No recent verified company-specific video clip queued for SYRE today (we never pad ticker pages with unrelated generic clips). Browse Macro Video Desk β†’

SYRE Investor FAQ & Complete 8-Part Research Index

100% OPEN ACCESS β€’ SEC EDGAR Γ— CBOE Γ— FRED

How profitable is Spyre Therapeutics Inc. (SYRE)?

In FY 2025 (10-K), SYRE converted $4.0B of revenue into a 0% gross margin, 0% operating margin, and $0 in free cash flow (0% FCF margin).