Genomics and synthetic biology are transforming healthcare through precision medicine and gene editing, putting ILMN, QURE and TXG in focus as the markets expand.
Why QURE Stock advanced +1.32% Today — RQD Quant Desk Flash
uniQure N.V. (QURE) carries a Roarable Rating of D+ (Sell) with 52/100 RQD Confidence due to weak cash-flow efficiency and sensitivity to current interest rates. Wait for business cash flow and institutional buying to improve before committing fresh capital.
Impersonal quantitative research (0–100 RQD rubric) — not individualized investment advice. Past performance does not guarantee future results. Full Disclaimer
20D Institutional Volume Accumulation (±12.5% realized swing band)
FRED Regime × Technicals: 39% of 52W Range • RSI-14 at 42.4 (NEUTRAL RANGE)
Dilution Drag (+1.92% YoY Shares) & executive Form 4 sales trim 15 pts from alignment
⚔️ Adversarial Opposing Case: What Could Spark a QURE Turnaround Squeeze
While QURE currently carries a cautious 52/100 (D+) rating due to Insider Conviction & Share Dilution (5/20), shorts face asymmetric squeeze risk if free cash flow inflects or management executes accretive buybacks.
Established market leader in Health Care with deep daily trading liquidity.
Options & Short-Covering Gamma: Reclaiming the 50-day SMA ($34.55) and Max Pain ($26.57) forces dealer call-delta covering toward $54.31.
Forensic Repair Trigger: Halting share dilution (Dilution Drag (+1.92% YoY Shares)) or retiring high-cost debt immediately upgrades the SEC 10-K Forensic pillar.
Why QURE Stock advanced +1.32% Today — RQD Quant Desk Flash
uniQure N.V. (QURE) advanced +1.32% to $25.30, trading at 39% of its 52-week range ($8.73 – $51.72). Stretched risk/reward at current multiples (-35% return on capital) under elevated 10-year interest-rate pressure.
- ▸Technical Tape: Trading at 39% of its 52-week range ($8.73 – $51.72) with RSI-14 at 42.4 (NEUTRAL RANGE).
- ▸Volatility Profile: Historical 20-day realized swing band of ±12.5% around $25.30 (no active unusual options sweep snapshot on file).
- ▸Fundamental Anchor: Roarable D+ (Sell) backed by 52% gross margin and $0 annual free cash flow.
uniQure shares closed at US$24.97 after a turbulent few years, and that mix of sharp swings and fresh clinical scrutiny now raises a straightforward question for investors about how the current market price lines up with
ClearPoint Neuro (NASDAQ:CLPT) reported third-quarter 2026 revenue growth of 36% as sales increased across its biologics and drug-delivery, neurosurgery navigation and therapy, and capital equipment and software business
~ uniQure to host earnings call on Wednesday, November 4, 2026 at 8:30 a.m. ET ~LEXINGTON, Mass. and AMSTERDAM, Oct. 28, 2026 (GLOBE NEWSWIRE) -- uniQure N.V. (NASDAQ: QURE), a leading gene therapy company advancing tran
Red-Light Warning Desk: Spotting SEC Cash-Flow & Dilution Risks Before Downgrades (Featuring QURE)
- ✓Walkthrough of QURE's RQD Radar, SEC cash-conversion gap & downside invalidation levels
- ✓3 asymmetric Bear/Hedge frameworks when 10-year Treasury yields stay elevated
- ✓Includes nightly RQD rating-change & forensic signal email alerts on your tracked stocks
QURE Dilution Monitor, Expectations Hurdle, Butterfly Connections & Policy Exposure
Multi-year comparable XBRL diluted share count not disclosed (ETF or recent listing).
vs. +6.0% actual YoY revenue growth (assuming 9.25% cost of equity & 16.5x terminal multiple).
No active Ellis Vennor swing setup published on QURE today. View full Setup Ledger →
No direct multi-tier Butterfly edges indexed yet for QURE. Explore sector supply chains on /butterfly.
📊 Quantitative Sector Peer Comparison, SEC Filing Delta & Investment FAQ (QURE)
1. Head-to-Head Health Care Peer Comparison (QURE vs. KLRA, NBTX, STOK, CMPS)
Industry: Biotechnology: Pharmaceutical Preparations (489 Tracked Issuers)Across 1016 tracked Health Care securities in the Roarable RQD universe, uniQure N.V. (QURE) ranks #316 by composite RQD confidence (52/100, grade D+) and #281 by equity capitalization ($1.75B). Within this direct 5-issuer industry benchmark cohort, QURE leads on earnings valuation at N/A trailing P/E, while STOK leads on capital efficiency and profitability with -6.1% ROIC and — gross margin. STOK currently holds the highest overall quantitative score in the immediate peer group at 59/100 (C-) compared with QURE at 52/100 (D+).
| Ticker / Company | Roarable Grade | RQD Score | Trailing P/E | Gross Margin | ROIC | 1D Change | Market Cap | Head-to-Head |
|---|---|---|---|---|---|---|---|---|
| QURE
ACTIVE
uniQure N.V. | D+ | 52/100 | — | — | -35.0% | +1.32% | $1.75B | Benchmark Subject |
| KLRA Kailera Therapeutics Inc. | D | 50/100 | — | — | — | -0.07% | $1.74B | /klra-vs-qure → |
| NBTX Nanobiotix S.A. | D+ | 52/100 | — | — | — | -0.53% | $1.72B | /nbtx-vs-qure → |
| STOK Stoke Therapeutics Inc. | C- | 59/100 | — | — | -6.1% | -0.23% | $1.70B | /stok-vs-qure → |
| CMPS COMPASS Pathways Plc American Depository Shares | D- | 37/100 | — | — | -35.0% | -0.73% | $1.69B | /cmps-vs-qure → |
2. Multi-Year SEC XBRL Revenue, Cash Flow & Balance-Sheet Trajectory (FY2023–FY2025)
SEC EDGAR 10-K • FILED 2025-12-31 • CIK 0001590560In its most recent audited fiscal period (FY2025, filed 2025-12-31), uniQure N.V. (QURE) reported GAAP revenue of $0 (N/A vs. FY2024 revenue of $0 ) , GAAP net income of -$199.0M, operating cash flow of -$178.0M, and free cash flow of -$178.4M (+4.1% YoY). On the balance sheet, QURE closed FY2025 with $824.9M in total assets against $49.7M in total debt (Altman Z-Score: N/A, Piotroski F-Score: 4/9).
| Fiscal Period | Filing Date | Revenue | Net Income | Operating Cash Flow | Free Cash Flow | Total Assets | Total Debt |
|---|---|---|---|---|---|---|---|
| FY2025 (FY) | 2025-12-31 | $0 | -$199.0M | -$178.0M | -$178.4M | $824.9M | $49.7M |
| FY2024 (FY) | 2024-12-31 | $0 | -$239.6M | -$182.7M | -$186.1M | $556.5M | $51.3M |
| FY2023 (FY) | 2023-12-31 | $0 | -$308.5M | -$145.9M | -$145.9M | — | — |
3. QURE Data-Verified Investor FAQ (RQD Rating, Sector Peers, SEC Forensics & Technicals)
✓ SCHEMA.ORG FAQPAGE JSON-LD ENABLEDIs QURE stock a Buy, Hold, or Sell right now according to Roarable's RQD model?
As of 2026-11-01, uniQure N.V. (NASDAQ: QURE) is rated D+ (Sell / SELL) by Roarable's 5-pillar RQD engine with a composite confidence score of 52/100 at a spot price of $25.30 (+1.32% 1D, market cap $1.75B). Pillar breakdown: Fundamental Cash Engine 6/20, Institutional 13F & Options Flow 14/20, Executive Insider Alignment 13/20, FRED Macro Regime Fit 14/20, and SEC Balance-Sheet Forensics 5/20. Across 1016 tracked Health Care issuers, QURE ranks #316 in composite RQD confidence.
How does QURE compare to KLRA and NBTX in the Health Care sector?
Within the Health Care sector (Biotechnology: Pharmaceutical Preparations), QURE carries a Roarable D+ (52/100 RQD), trailing P/E of N/A, gross margin of —, and ROIC of -35.0%. By comparison, KLRA (Kailera Therapeutics Inc.) holds a D grade (50/100 RQD, P/E N/A, ROIC —, cap $1.74B) and NBTX (Nanobiotix S.A.) posts a D+ grade (52/100 RQD, P/E N/A, ROIC —, cap $1.72B). Among the 5-stock peer group, QURE leads on earnings multiple (N/A) while STOK leads on capital efficiency (-6.1% ROIC).
What are the biggest fundamental strengths and SEC risk factors for QURE?
Per QURE's SEC EDGAR XBRL 10-K filing (FY2025, filed 2025-12-31, CIK 0001590560), uniQure N.V. generated $0 in revenue, -$199.0M in net income, and -$178.4M in free cash flow against $824.9M in total assets and $49.7M in total debt. Key quantitative strengths: Established market leader in Health Care with deep daily trading liquidity.. Primary risk factors monitored: Company executives have done more routine share selling than personal cash buying lately.. Institutional options positioning shows a 50% call / 50% put premium split.
Where is QURE trading relative to its 50-day, 200-day, and 52-week technical levels?
QURE last traded at $25.30 (+1.32% on volume of 1,713,465 shares), positioning the stock -26.77% below its 50-day simple moving average ($34.55) and -14.67% below its 200-day simple moving average ($29.65). Across its 52-week range of $8.73 to $51.72, QURE sits at the 38.5% percentile with a 14-day RSI of 42.4 (NEUTRAL RANGE) and an implied next-earnings move of ±12.5% ($22.14 to $28.46).
QURE Investor FAQ & Complete 8-Part Research Index
100% OPEN ACCESS • SEC EDGAR × CBOE × FREDWhy is QURE stock moving today?
Why QURE Stock advanced +1.32% Today — RQD Quant Desk Flash. Stretched risk/reward at current multiples (-35% return on capital) under elevated 10-year interest-rate pressure.