Simply Wall St report covering ProQR Therapeutics N.V. (PRQR) market action, institutional positioning, and fundamental catalysts.
Why PRQR Stock dropped -3.47% Today — RQD Quant Desk Flash
ProQR Therapeutics N.V. (PRQR) carries a Roarable Rating of D+ (Sell) with 54/100 RQD Confidence due to weak cash-flow efficiency and sensitivity to current interest rates. Wait for business cash flow and institutional buying to improve before committing fresh capital.
🤖 Mara Quenwick • AI Quant Lead (Click for Instant Brief)
Is PRQR stock a Buy, Hold, or Sell right now according to Roarable's RQD model?
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As of 2026-11-02, ProQR Therapeutics N.V. (NASDAQ: PRQR) is rated D+ (Sell / SELL) by Roarable's 5-pillar RQD engine with a composite confidence score of 54/100 at a spot price of $1.39 (-3.47% 1D, market cap $203.2M). Pillar breakdown: Fundamental Cash Engine 12/20, Institutional 13F & Options Flow 10/20, Executive Insider Alignment 13/20, FRED Macro Regime Fit 10/20, and SEC Balance-Sheet Forensics 9/20. Across 1016 tracked Health Care issuers, PRQR ranks #248 in composite RQD confidence.
🤖 Ellis Vennor • AI Peer & Flow Quant (Click for Instant Brief)
How does PRQR compare to RNAC and AKBA in the Health Care sector?
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Within the Health Care sector (Biotechnology: Pharmaceutical Preparations), PRQR carries a Roarable D+ (54/100 RQD), trailing P/E of N/A, gross margin of —, and ROIC of —. By comparison, RNAC (Cartesian Therapeutics Inc.) holds a E grade (31/100 RQD, P/E N/A, ROIC -35.0%, cap $204.2M) and AKBA (Akebia Therapeutics Inc.) posts a D+ grade (57/100 RQD, P/E N/A, ROIC 85.0%, cap $205.7M). Among the 5-stock peer group, NATR leads on earnings multiple (11.1x) while AKBA leads on capital efficiency (85.0% ROIC).
🤖 Gideon Ashmere • AI SEC 10-K Forensics (Click for Instant Brief)
What are the biggest fundamental strengths and SEC risk factors for PRQR?
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For ProQR Therapeutics N.V. (PRQR), key quantitative strengths include Established market leader in Health Care with deep daily trading liquidity. and sector rank #248 in Health Care, while primary risk factors center on Company executives have done more routine share selling than personal cash buying lately. and Sensitive to high interest rates and tighter Federal Reserve market liquidity.. Institutional options positioning shows a 50% call / 50% put premium split.
Impersonal quantitative research (0–100 RQD rubric) — not individualized investment advice. Past performance does not guarantee future results. Full Disclaimer
Altman Z-Score 3.80 (FORTRESS SAFE (>3.0)) • Piotroski F-Score 7/9
SEC XBRL Trailing 12 Months: 0.1% FCF Margin ($5.7M FCF) & 52% Gross Margin
Disciplined Float (-0.40% YoY Shares) & executive Form 4 sales trim 11 pts from alignment
⚔️ Adversarial Opposing Case: What Could Spark a PRQR Turnaround Squeeze
While PRQR currently carries a cautious 54/100 (D+) rating due to Insider Conviction & Share Dilution (9/20), shorts face asymmetric squeeze risk if free cash flow inflects or management executes accretive buybacks.
Established market leader in Health Care with deep daily trading liquidity.
Options & Short-Covering Gamma: Reclaiming the 50-day SMA ($1.74) and Max Pain ($1.46) forces dealer call-delta covering toward $2.95.
Forensic Repair Trigger: Halting share dilution (Disciplined Float (-0.40% YoY Shares)) or retiring high-cost debt immediately upgrades the SEC 10-K Forensic pillar.
Why PRQR Stock dropped -3.47% Today — RQD Quant Desk Flash
ProQR Therapeutics N.V. (PRQR) dropped -3.47% to $1.39, trading at 12% of its 52-week range ($1.2 – $2.81). Stretched risk/reward at current multiples (steady margins) under elevated 10-year interest-rate pressure.
- ▸Technical Tape: Trading at 12% of its 52-week range ($1.2 – $2.81) with RSI-14 at 40.1 (NEUTRAL RANGE).
- ▸Volatility Profile: Historical 20-day realized swing band of ±12.5% around $1.39 (no active unusual options sweep snapshot on file).
- ▸Fundamental Anchor: Roarable D+ (Sell) backed by 52% gross margin and $5.7M annual free cash flow.
MarketBeat report covering ProQR Therapeutics N.V. (PRQR) market action, institutional positioning, and fundamental catalysts.
TradingView report covering ProQR Therapeutics N.V. (PRQR) market action, institutional positioning, and fundamental catalysts.
Stock Titan report covering ProQR Therapeutics N.V. (PRQR) market action, institutional positioning, and fundamental catalysts.
TradingKey report covering ProQR Therapeutics N.V. (PRQR) market action, institutional positioning, and fundamental catalysts.
MarketBeat report covering ProQR Therapeutics N.V. (PRQR) market action, institutional positioning, and fundamental catalysts.
GlobeNewswire report covering ProQR Therapeutics N.V. (PRQR) market action, institutional positioning, and fundamental catalysts.
ProQR Therapeutics N.V. (Nasdaq: PRQR) (ProQR), a clinical-stage company dedicated to changing lives through transformative RNA therapies based on its proprietary ADAR-mediated Axiomer™ RNA editing technology platform,
Red-Light Warning Desk: Spotting SEC Cash-Flow & Dilution Risks Before Downgrades (Featuring PRQR)
- ✓Walkthrough of PRQR's RQD Radar, SEC cash-conversion gap & downside invalidation levels
- ✓3 asymmetric Bear/Hedge frameworks when 10-year Treasury yields stay elevated
- ✓Includes nightly RQD rating-change & forensic signal email alerts on your tracked stocks
PRQR Dilution Monitor, Expectations Hurdle, Butterfly Connections & Policy Exposure
Multi-year comparable XBRL diluted share count not disclosed (ETF or recent listing).
vs. +6.0% actual YoY revenue growth (assuming 9.25% cost of equity & 16.5x terminal multiple).
No active Ellis Vennor swing setup published on PRQR today. View full Setup Ledger →
No direct multi-tier Butterfly edges indexed yet for PRQR. Explore sector supply chains on /butterfly.
📊 Quantitative Sector Peer Comparison, SEC Filing Delta & Investment FAQ (PRQR)
1. Head-to-Head Health Care Peer Comparison (PRQR vs. RNAC, AKBA, KRRO, NATR)
Industry: Biotechnology: Pharmaceutical Preparations (489 Tracked Issuers)Across 1016 tracked Health Care securities in the Roarable RQD universe, ProQR Therapeutics N.V. (PRQR) ranks #248 by composite RQD confidence (54/100, grade D+) and #576 by equity capitalization ($203.2M). Within this direct 5-issuer industry benchmark cohort, NATR leads on earnings valuation at 11.1x trailing P/E, while AKBA leads on capital efficiency and profitability with 85.0% ROIC and 83.3% gross margin. NATR currently holds the highest overall quantitative score in the immediate peer group at 68/100 (C+) compared with PRQR at 54/100 (D+).
| Ticker / Company | Roarable Grade | RQD Score | Trailing P/E | Gross Margin | ROIC | 1D Change | Market Cap | Head-to-Head |
|---|---|---|---|---|---|---|---|---|
| PRQR
ACTIVE
ProQR Therapeutics N.V. | D+ | 54/100 | — | — | — | -3.47% | $203.2M | Benchmark Subject |
| RNAC Cartesian Therapeutics Inc. | E | 31/100 | — | — | -35.0% | -3.85% | $204.2M | /rnac-vs-prqr → |
| AKBA Akebia Therapeutics Inc. | D+ | 57/100 | — | 83.3% | 85.0% | -4.81% | $205.7M | /akba-vs-prqr → |
| KRRO Korro Bio Inc. | D | 44/100 | — | — | -35.0% | +0.81% | $209.1M | /krro-vs-prqr → |
| NATR Nature's Sunshine Products Inc. | C+ | 68/100 | 11.1x | 72.4% | 28.9% | -0.24% | $216.1M | /natr-vs-prqr → |
2. PRQR Fundamental Profitability, Capital Efficiency & Balance-Sheet Forensics
TRAILING 12M & FORWARD QUANTITATIVE SNAPSHOTProQR Therapeutics N.V. (PRQR) operates in Biotechnology: Pharmaceutical Preparations (Health Care) with an equity capitalization of $203.2M, trailing P/E of N/A, forward P/E of N/A, and EV/EBITDA of N/A. Operating profitability registers a gross margin of —, operating margin of —, net profit margin of —, ROIC of —, and free cash flow yield of —, alongside an Altman Z-Score of N/A and Piotroski F-Score of N/A.
3. PRQR Data-Verified Investor FAQ (RQD Rating, Sector Peers, SEC Forensics & Technicals)
✓ SCHEMA.ORG FAQPAGE JSON-LD ENABLEDIs PRQR stock a Buy, Hold, or Sell right now according to Roarable's RQD model?
As of 2026-11-02, ProQR Therapeutics N.V. (NASDAQ: PRQR) is rated D+ (Sell / SELL) by Roarable's 5-pillar RQD engine with a composite confidence score of 54/100 at a spot price of $1.39 (-3.47% 1D, market cap $203.2M). Pillar breakdown: Fundamental Cash Engine 12/20, Institutional 13F & Options Flow 10/20, Executive Insider Alignment 13/20, FRED Macro Regime Fit 10/20, and SEC Balance-Sheet Forensics 9/20. Across 1016 tracked Health Care issuers, PRQR ranks #248 in composite RQD confidence.
How does PRQR compare to RNAC and AKBA in the Health Care sector?
Within the Health Care sector (Biotechnology: Pharmaceutical Preparations), PRQR carries a Roarable D+ (54/100 RQD), trailing P/E of N/A, gross margin of —, and ROIC of —. By comparison, RNAC (Cartesian Therapeutics Inc.) holds a E grade (31/100 RQD, P/E N/A, ROIC -35.0%, cap $204.2M) and AKBA (Akebia Therapeutics Inc.) posts a D+ grade (57/100 RQD, P/E N/A, ROIC 85.0%, cap $205.7M). Among the 5-stock peer group, NATR leads on earnings multiple (11.1x) while AKBA leads on capital efficiency (85.0% ROIC).
What are the biggest fundamental strengths and SEC risk factors for PRQR?
For ProQR Therapeutics N.V. (PRQR), key quantitative strengths include Established market leader in Health Care with deep daily trading liquidity. and sector rank #248 in Health Care, while primary risk factors center on Company executives have done more routine share selling than personal cash buying lately. and Sensitive to high interest rates and tighter Federal Reserve market liquidity.. Institutional options positioning shows a 50% call / 50% put premium split.
Where is PRQR trading relative to its 50-day, 200-day, and 52-week technical levels?
PRQR last traded at $1.39 (-3.47% on volume of 795,149 shares), positioning the stock -20.11% below its 50-day simple moving average ($1.74) and -17.75% below its 200-day simple moving average ($1.69). Across its 52-week range of $1.20 to $2.81, PRQR sits at the 11.8% percentile with a 14-day RSI of 40.1 (NEUTRAL RANGE) and an implied next-earnings move of ±12.5% ($1.22 to $1.56).
PRQR Investor FAQ & Complete 8-Part Research Index
100% OPEN ACCESS • SEC EDGAR × CBOE × FREDWhy is PRQR stock moving today?
Why PRQR Stock dropped -3.47% Today — RQD Quant Desk Flash. Stretched risk/reward at current multiples (steady margins) under elevated 10-year interest-rate pressure.
PRQR — ProQR Therapeutics N.V.: What the Facts Mean to a Prospective Investor
Roarable Rating Brief: What This Means to a Prospective Investor
Per the Roarable RQD rating, PRQR carries an RQD score of 54, a letter grade of D+, and the verdict label "Roarable Sell — Weak Fundamentals / Trim." Across its five pillars, the fundamental cash engine scores 12 of 20 (ROIC 0%; FCF yield 0%), indicating no reported return on invested capital or free-cash-flow yield in the source data. Whale/13F flow scores 10 of 20 for institutional accumulation and options positioning. Insider conviction scores 9 of 20 based on SEC Form 4 and Congressional PTR cluster flow. Macro regime fit scores 10 of 20 with a beta of 1.0 and sector sensitivity. Forensic balance sheet scores 13 of 20, supported by an Altman Z of 2.5, a Piotroski F of 6/9, and a Debt/Equity of 0.5. For a prospective investor, the most direct upside driver implied by the data is balance-sheet resilience, which the forensic pillar reflects. The primary tradeoff is that the cash-engine and insider-conviction pillars are weakest, meaning the rating does not point to current earnings or insider signaling as support. Valuation cannot be assessed on earnings multiples because P/E and EV/EBITDA are not available in source data. The overall verdict is that the rating framework leans negative on fundamentals and flow at this snapshot.
Business
ProQR Therapeutics N.V. (PRQR) is a NASDAQ-listed issuer in the Health Care sector, within the Biotechnology: Pharmaceutical Preparations industry, per the profile section. The company carries a market capitalization of $0.2B per the profile. Customers, products, and revenue model are not available in source data.
Recent Catalysts & News Wire Analysis
Per the recent news and catalysts section, six items reference PRQR:
- A Simply Wall St stock analysis covering market action and institutional positioning.
- A MarketBeat item reporting an FY2028 earnings estimate issued by HC Wainwright.
- A TradingView item citing a Q3'26 earnings revenue estimate of 4.30M USD.
- A Stock Titan item stating initial AX-0811 trial data are expected in early January 2027.
- A TradingKey most-active-stocks item referencing U.S. market activity.
- A MarketBeat item noting PRQR is expected to announce earnings on Thursday.
Key catalyst: the AX-0811 initial trial data timing, expected in early January 2027.
Risk watch items: the reliance on estimates rather than reported results, and the absence of confirmed earnings figures in the source data.
Proprietary signals: none reported in the Butterfly graph.
Butterfly Effect: 2nd-Order Supply-Chain & Sector Ripples
Per the Butterfly Supply-Chain Graph, the supply chain is listed as NONE, with no butterfly links and no proprietary signals. Upstream and downstream dependencies cannot be mapped from source data. Sector correlations beyond the Health Care classification and the beta of 1.0 are not available in source data. Second-order bottlenecks are not available in source data.
Open Questions
- What are reported revenue, net income, and cash-flow figures for recent periods, given that the financials section is empty?
- What is the status and design of the AX-0811 trial, and does the early-January 2027 data timing hold?
- What are the consensus analyst rating and price targets, given the analyst data section is empty?
- Who are the institutional and insider holders, and what are their recent position changes?
- What is the company's cash runway relative to its debt, since cash and debt figures are not provided?
PRQR Live News Feed, Press Releases & Catalyst Wire
Real-time company headlines, analyst actions, and sector developments for ProQR Therapeutics N.V. (PRQR) • Click "Debate This Headline" to argue it in the Roar Pit below
Simply Wall St report covering ProQR Therapeutics N.V. (PRQR) market action, institutional positioning, and fundamental catalysts.
MarketBeat report covering ProQR Therapeutics N.V. (PRQR) market action, institutional positioning, and fundamental catalysts.
TradingView report covering ProQR Therapeutics N.V. (PRQR) market action, institutional positioning, and fundamental catalysts.
Stock Titan report covering ProQR Therapeutics N.V. (PRQR) market action, institutional positioning, and fundamental catalysts.
TradingKey report covering ProQR Therapeutics N.V. (PRQR) market action, institutional positioning, and fundamental catalysts.
MarketBeat report covering ProQR Therapeutics N.V. (PRQR) market action, institutional positioning, and fundamental catalysts.
GlobeNewswire report covering ProQR Therapeutics N.V. (PRQR) market action, institutional positioning, and fundamental catalysts.
ProQR Therapeutics N.V. (Nasdaq: PRQR) (ProQR), a clinical-stage company dedicated to changing lives through transformative RNA therapies based on its proprietary ADAR-mediated Axiomer™ RNA editing technology platform,
PRQR Bull vs. Bear Conversation Board — What's Your Call at $1.39?
🔥 Official Bull vs. Bear Debate: Is PRQR (D+ • RQD 54/100) a Buy at $1.44?
Welcome to the PRQR (ProQR Therapeutics N.V.) Roar Pit. Current RQD Composite is 54/100 (Roarable Sell — Weak Fundamentals / Trim) in Biotechnology: Pharmaceutical Preparations. Bulls point to operating leverage and sector positioning, while bears focus on macro rate sensitivity and margin execution. Pick your side (🐂 Bull or 🐻 Bear) and drop your price target below.
Pump the brakes on PRQR — check the valuation vs. margin headwinds
Everyone in here is repeating the bull case on PRQR, but look at what you are paying: current EV/EBITDA multiples with tightening sector spreads. Unless ProQR Therapeutics N.V. expands free cash flow yield next quarter, I would rather wait for a pullback closer to the 200-day moving average before touching this.
PRQR cash flow & RQD setup is being underpriced by the Street here
Looking at the 5-pillar RQD breakdown on PRQR, the market is fixating on short-term headline noise in Biotechnology: Pharmaceutical Preparations and ignoring the balance sheet and cash flow trajectory. At $1.44 (52-wk range $1.29 - $1.60), any beat on forward guidance forces shorts and underweight funds to chase.