Prime Medicine Inc. (PRME) carries a Roarable Rating of E (Strong Sell) with 21/100 RQD Confidence due to weak cash-flow efficiency and sensitivity to current interest rates. Wait for business cash flow and institutional buying to improve before committing fresh capital.
Impersonal quantitative research (0–100 RQD rubric) — not individualized investment advice. Past performance does not guarantee future results. Full Disclaimer
20D Institutional Volume Accumulation (±12.5% realized swing band)
FRED Regime × Technicals: 79% of 52W Range • RSI-14 at 61.5 (BULLISH MOMENTUM)
Dilution Drag (+2.48% YoY Shares) & executive Form 4 sales trim 16 pts from alignment
While PRME currently carries a cautious 21/100 (E) rating due to Insider Conviction & Share Dilution (4/20), shorts face asymmetric squeeze risk if free cash flow inflects or management executes accretive buybacks.
Established market leader in Health Care with deep daily trading liquidity.
Options & Short-Covering Gamma: Reclaiming the 50-day SMA ($3.54) and Max Pain ($5.50) forces dealer call-delta covering toward $6.21.
Forensic Repair Trigger: Halting share dilution (Dilution Drag (+2.48% YoY Shares)) or retiring high-cost debt immediately upgrades the SEC 10-K Forensic pillar.
Prime Medicine Inc. (PRME) dropped -2.24% to $5.24, trading at 79% of its 52-week range ($2.67 – $5.91). Stretched risk/reward at current multiples (-35% return on capital) under elevated 10-year interest-rate pressure.
Prime Medicine, Inc. (PRME) witnessed a jump in share price last session on above-average trading volume. The latest trend in earnings estimate revisions for the stock doesn't suggest further strength down the road.
Under the FDA’s new draft guidance, companies can file one application that covers several versions of the same gene-editing treatment, as long as each version aims to make the same kind of genetic correction.
Multi-year comparable XBRL diluted share count not disclosed (ETF or recent listing).
vs. +55.3% actual YoY revenue growth (assuming 9.25% cost of equity & 16.5x terminal multiple).
No active Ellis Vennor swing setup published on PRME today. View full Setup Ledger →
No direct multi-tier Butterfly edges indexed yet for PRME. Explore sector supply chains on /butterfly.
Across 1016 tracked Health Care securities in the Roarable RQD universe, Prime Medicine Inc. (PRME) ranks #1008 by composite RQD confidence (21/100, grade E) and #366 by equity capitalization ($950.4M). Within this direct 5-issuer industry benchmark cohort, PRME leads on earnings valuation at N/A trailing P/E, while PRME leads on capital efficiency and profitability with -35.0% ROIC and — gross margin. ODTX currently holds the highest overall quantitative score in the immediate peer group at 59/100 (C-) compared with PRME at 21/100 (E).
| Ticker / Company | Roarable Grade | RQD Score | Trailing P/E | Gross Margin | ROIC | 1D Change | Market Cap | Head-to-Head |
|---|---|---|---|---|---|---|---|---|
| PRME
ACTIVE
Prime Medicine Inc. | E | 21/100 | — | — | -35.0% | -2.24% | $950.4M | Benchmark Subject |
| ODTX Odyssey Therapeutics Inc. | C- | 59/100 | — | — | — | +1.48% | $953.0M | /odtx-vs-prme → |
| MGTX MeiraGTx Holdings plc | E | 27/100 | — | — | -35.0% | -0.46% | $932.1M | /mgtx-vs-prme → |
| GLUE Monte Rosa Therapeutics Inc. | E | 33/100 | — | — | -35.0% | +0.18% | $927.4M | /glue-vs-prme → |
| CGEM Cullinan Therapeutics Inc. | D- | 36/100 | — | — | -35.0% | -0.71% | $994.3M | /cgem-vs-prme → |
In its most recent audited fiscal period (FY2025, filed 2025-12-31), Prime Medicine Inc. (PRME) reported GAAP revenue of $4.6M (+55.3% vs. FY2024 revenue of $3.0M ) , GAAP net income of -$201.1M, operating cash flow of -$162.6M, and free cash flow of -$167.1M (-28.4% YoY). On the balance sheet, PRME closed FY2025 with $342.7M in total assets against $0 in total debt (Altman Z-Score: 0.20, Piotroski F-Score: 3/9).
| Fiscal Period | Filing Date | Revenue | Net Income | Operating Cash Flow | Free Cash Flow | Total Assets | Total Debt |
|---|---|---|---|---|---|---|---|
| FY2025 (FY) | 2025-12-31 | $4.6M | -$201.1M | -$162.6M | -$167.1M | $342.7M | — |
| FY2024 (FY) | 2024-12-31 | $3.0M | -$195.9M | -$122.9M | -$130.2M | $297.5M | — |
| FY2023 (FY) | 2023-12-31 | $0 | -$198.1M | -$165.4M | -$165.4M | — | — |
As of 2026-11-01, Prime Medicine Inc. (NASDAQ: PRME) is rated E (Strong Sell / SELL) by Roarable's 5-pillar RQD engine with a composite confidence score of 21/100 at a spot price of $5.24 (-2.24% 1D, market cap $950.4M). Pillar breakdown: Fundamental Cash Engine 3/20, Institutional 13F & Options Flow 8/20, Executive Insider Alignment 3/20, FRED Macro Regime Fit 6/20, and SEC Balance-Sheet Forensics 3/20. Across 1016 tracked Health Care issuers, PRME ranks #1008 in composite RQD confidence.
Within the Health Care sector (Biotechnology: Biological Products (No Diagnostic Substances)), PRME carries a Roarable E (21/100 RQD), trailing P/E of N/A, gross margin of —, and ROIC of -35.0%. By comparison, ODTX (Odyssey Therapeutics Inc.) holds a C- grade (59/100 RQD, P/E N/A, ROIC —, cap $953.0M) and MGTX (MeiraGTx Holdings plc) posts a E grade (27/100 RQD, P/E N/A, ROIC -35.0%, cap $932.1M). Among the 5-stock peer group, PRME leads on earnings multiple (N/A) while PRME leads on capital efficiency (-35.0% ROIC).
Per PRME's SEC EDGAR XBRL 10-K filing (FY2025, filed 2025-12-31, CIK 0001894562), Prime Medicine Inc. generated $4.6M in revenue (+55.3% YoY), -$201.1M in net income, and -$167.1M in free cash flow against $342.7M in total assets and $0 in total debt. Key quantitative strengths: Established market leader in Health Care with deep daily trading liquidity.. Primary risk factors monitored: Company executives have done more routine share selling than personal cash buying lately.. Institutional options positioning shows a 50% call / 50% put premium split.
PRME last traded at $5.24 (-2.24% on volume of 10,354,787 shares), positioning the stock +48.02% above its 50-day simple moving average ($3.54) and +50.14% above its 200-day simple moving average ($3.49). Across its 52-week range of $2.67 to $5.91, PRME sits at the 79.3% percentile with a 14-day RSI of 61.5 (BULLISH MOMENTUM) and an implied next-earnings move of ±12.5% ($4.58 to $5.90).
Why PRME Stock dropped -2.24% Today — RQD Quant Desk Flash. Stretched risk/reward at current multiples (-35% return on capital) under elevated 10-year interest-rate pressure.
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