Palisade Bio Inc. (PALI) carries a Roarable Rating of D- (Sell) with 43/100 RQD Confidence due to weak cash-flow efficiency and sensitivity to current interest rates. Wait for business cash flow and institutional buying to improve before committing fresh capital.
As of 2026-11-02, Palisade Bio Inc. (NASDAQ: PALI) is rated D- (Sell / SELL) by Roarable's 5-pillar RQD engine with a composite confidence score of 43/100 at a spot price of $1.19 (0.00% 1D, market cap $207.4M). Pillar breakdown: Fundamental Cash Engine 9/20, Institutional 13F & Options Flow 9/20, Executive Insider Alignment 10/20, FRED Macro Regime Fit 12/20, and SEC Balance-Sheet Forensics 3/20. Across 1016 tracked Health Care issuers, PALI ranks #460 in composite RQD confidence.
Within the Health Care sector (Biotechnology: Biological Products (No Diagnostic Substances)), PALI carries a Roarable D- (43/100 RQD), trailing P/E of N/A, gross margin of —, and ROIC of -35.0%. By comparison, ARTV (Artiva Biotherapeutics Inc.) holds a D- grade (39/100 RQD, P/E N/A, ROIC -35.0%, cap $206.8M) and DTIL (Precision BioSciences Inc.) posts a E grade (24/100 RQD, P/E N/A, ROIC -35.0%, cap $205.4M). Among the 5-stock peer group, CGEN leads on earnings multiple (5.5x) while CGEN leads on capital efficiency (85.0% ROIC).
Per PALI's SEC EDGAR XBRL 10-K filing (FY2025, filed 2025-12-31, CIK 0001357459), Palisade Bio Inc. generated $0 in revenue, -$16.8M in net income, and -$10.8M in free cash flow against $134.3M in total assets and $0 in total debt. Key quantitative strengths: Established market leader in Health Care with deep daily trading liquidity.. Primary risk factors monitored: Company executives have done more routine share selling than personal cash buying lately.. Institutional options positioning shows a 50% call / 50% put premium split.
Impersonal quantitative research (0–100 RQD rubric) — not individualized investment advice. Past performance does not guarantee future results. Full Disclaimer
FRED Regime × Technicals: 5% of 52W Range • RSI-14 at 30.1 (OVERSOLD (<32))
Altman Z-Score 3.80 (FORTRESS SAFE (>3.0)) • Piotroski F-Score 2/9
Dilution Drag (+2.48% YoY Shares) & executive Form 4 sales trim 16 pts from alignment
While PALI currently carries a cautious 43/100 (D-) rating due to Insider Conviction & Share Dilution (4/20), shorts face asymmetric squeeze risk if free cash flow inflects or management executes accretive buybacks.
Established market leader in Health Care with deep daily trading liquidity.
Options & Short-Covering Gamma: Reclaiming the 50-day SMA ($1.65) and Max Pain ($1.25) forces dealer call-delta covering toward $3.00.
Forensic Repair Trigger: Halting share dilution (Dilution Drag (+2.48% YoY Shares)) or retiring high-cost debt immediately upgrades the SEC 10-K Forensic pillar.
Palisade Bio Inc. (PALI) slipped 0.00% to $1.19, trading at 5% of its 52-week range ($1.1 – $2.86). Stretched risk/reward at current multiples (-35% return on capital) under elevated 10-year interest-rate pressure.
PALI-2108 is an investigational, gut-activated, once-daily oral PDE4 inhibitor prodrug designed for sustained exposure and anti-inflammatory activity with the potential to improve tolerability 29 of 30 planned U.S. sites
PALI-2108 is an investigational, gut-activated, once-daily oral PDE4 inhibitor prodrug designed for sustained exposure and anti-inflammatory activity with the potential to improve tolerability29 of 30 planned U.S. sites
Five-patient Phase 1b Crohn’s disease cohort showed a 47.5% reduction in mean endoscopic disease activity and a 58.8% reduction in mean fecal calprotectin after 14 days Intestinal exposure and tissue analyses strengthen
linical and translational findings presented in one oral presentation and three moderated posters at United European Gastroenterology (UEG) Week 2026, held October 17–20 in Barcelona, Spain. The findings connect
Multi-year comparable XBRL diluted share count not disclosed (ETF or recent listing).
vs. +6.0% actual YoY revenue growth (assuming 9.25% cost of equity & 16.5x terminal multiple).
No active Ellis Vennor swing setup published on PALI today. View full Setup Ledger →
No direct multi-tier Butterfly edges indexed yet for PALI. Explore sector supply chains on /butterfly.
Across 1016 tracked Health Care securities in the Roarable RQD universe, Palisade Bio Inc. (PALI) ranks #460 by composite RQD confidence (43/100, grade D-) and #571 by equity capitalization ($207.4M). Within this direct 5-issuer industry benchmark cohort, CGEN leads on earnings valuation at 5.5x trailing P/E, while CGEN leads on capital efficiency and profitability with 85.0% ROIC and 87.3% gross margin. CGEN currently holds the highest overall quantitative score in the immediate peer group at 78/100 (B+) compared with PALI at 43/100 (D-).
| Ticker / Company | Roarable Grade | RQD Score | Trailing P/E | Gross Margin | ROIC | 1D Change | Market Cap | Head-to-Head |
|---|---|---|---|---|---|---|---|---|
| PALI
ACTIVE
Palisade Bio Inc. | D- | 43/100 | — | — | -35.0% | 0.00% | $207.4M | Benchmark Subject |
| ARTV Artiva Biotherapeutics Inc. | D- | 39/100 | — | — | -35.0% | -1.05% | $206.8M | /artv-vs-pali → |
| DTIL Precision BioSciences Inc. | E | 24/100 | — | — | -35.0% | -0.40% | $205.4M | /dtil-vs-pali → |
| PLX Protalix BioTherapeutics Inc. | E | 28/100 | — | 48.8% | -13.0% | +0.77% | $210.3M | /plx-vs-pali → |
| CGEN Compugen Ltd. | B+ | 78/100 | 5.5x | 87.3% | 85.0% | +1.49% | $193.0M | /cgen-vs-pali → |
In its most recent audited fiscal period (FY2025, filed 2025-12-31), Palisade Bio Inc. (PALI) reported GAAP revenue of $0 (N/A vs. FY2024 revenue of $0 , and -100.0% cumulative change since FY2023) , GAAP net income of -$16.8M, operating cash flow of -$10.8M, and free cash flow of -$10.8M (+11.0% YoY). On the balance sheet, PALI closed FY2025 with $134.3M in total assets against $0 in total debt (Altman Z-Score: N/A, Piotroski F-Score: 2/9).
| Fiscal Period | Filing Date | Revenue | Net Income | Operating Cash Flow | Free Cash Flow | Total Assets | Total Debt |
|---|---|---|---|---|---|---|---|
| FY2025 (FY) | 2025-12-31 | $0 | -$16.8M | -$10.8M | -$10.8M | $134.3M | — |
| FY2024 (FY) | 2024-12-31 | $0 | -$14.4M | -$12.2M | -$12.2M | $10.9M | — |
| FY2023 (FY) | 2023-12-31 | $250.0K | -$12.3M | -$11.1M | -$11.1M | — | — |
As of 2026-11-02, Palisade Bio Inc. (NASDAQ: PALI) is rated D- (Sell / SELL) by Roarable's 5-pillar RQD engine with a composite confidence score of 43/100 at a spot price of $1.19 (0.00% 1D, market cap $207.4M). Pillar breakdown: Fundamental Cash Engine 9/20, Institutional 13F & Options Flow 9/20, Executive Insider Alignment 10/20, FRED Macro Regime Fit 12/20, and SEC Balance-Sheet Forensics 3/20. Across 1016 tracked Health Care issuers, PALI ranks #460 in composite RQD confidence.
Within the Health Care sector (Biotechnology: Biological Products (No Diagnostic Substances)), PALI carries a Roarable D- (43/100 RQD), trailing P/E of N/A, gross margin of —, and ROIC of -35.0%. By comparison, ARTV (Artiva Biotherapeutics Inc.) holds a D- grade (39/100 RQD, P/E N/A, ROIC -35.0%, cap $206.8M) and DTIL (Precision BioSciences Inc.) posts a E grade (24/100 RQD, P/E N/A, ROIC -35.0%, cap $205.4M). Among the 5-stock peer group, CGEN leads on earnings multiple (5.5x) while CGEN leads on capital efficiency (85.0% ROIC).
Per PALI's SEC EDGAR XBRL 10-K filing (FY2025, filed 2025-12-31, CIK 0001357459), Palisade Bio Inc. generated $0 in revenue, -$16.8M in net income, and -$10.8M in free cash flow against $134.3M in total assets and $0 in total debt. Key quantitative strengths: Established market leader in Health Care with deep daily trading liquidity.. Primary risk factors monitored: Company executives have done more routine share selling than personal cash buying lately.. Institutional options positioning shows a 50% call / 50% put premium split.
PALI last traded at $1.19 (0.00% on volume of 3,506,294 shares), positioning the stock -27.88% below its 50-day simple moving average ($1.65) and -35.68% below its 200-day simple moving average ($1.85). Across its 52-week range of $1.10 to $2.86, PALI sits at the 5.1% percentile with a 14-day RSI of 30.1 (OVERSOLD (<32)) and an implied next-earnings move of ±12.5% ($1.04 to $1.34).
Why PALI Stock Traded Steady Today — RQD Quant Desk Flash. Stretched risk/reward at current multiples (-35% return on capital) under elevated 10-year interest-rate pressure.
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